摘要
目的:观察荷瘤导致小鼠的抑郁状态和氟西汀对荷瘤小鼠抑郁状态的改善作用.方法:肝癌H22腹水瘤细胞小鼠腋下接种, 建立荷瘤小鼠模型, 采用利血平诱导眼睑下垂、尾悬挂、自主活动3种方法观察抑郁状态.结果: 荷瘤小鼠与正常小鼠相比, 利血平导致眼睑下垂得分, 尾悬挂的失望时间及自主活动数均明显变化(P<0.05); 应用氟西汀(10～40 mg·kg-1, ×11 d, po)后, 荷瘤小鼠所产生的抑郁状态的各项参数均有明显改善(P<0.01).结论: 荷瘤可导致小鼠产生一定的抑郁状态, 氟西汀具有明显改善荷瘤小鼠抑郁状态的作用.
AIM：To observe tumor-bearing induced depression and the antidepressive effects of fluoxetine in mice. METHODS：The tumor-bearing mice were created through hepatoma H22 cells. The reserpine reversal test, the tail suspension test and the spontaneous motor activity measurement were adopted to eveluate the depressive states. RESULTS： Compared with the control mice, ptosis scores, hopeless time and times of spontaneous motor activity were significantly changed in those ot the tumor-beanng mice respectively （ P 〈 0. 05 ）. Fluoxetine （ 10 ～ 40 mg · kg^- 1, ×11 d, po） could reverse the tumor-bearing induced depressive states （ P 〈 0. 01 ）. CONCLUSION ： Fluoxetine could improve the depression induced by tumor-bearing in mice.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2005年第10期757-760,共4页
Chinese Journal of New Drugs and Clinical Remedies
基金
上海市教委重点学科科研基金(NO2003JY04)
关键词
氟西汀
抑郁症
利血平
荷瘤
小鼠尾悬挂
自主活动
fluoxetine
depression
reserpine
tumor-bearing
tail suspension test
spontaneous motor activity
