转反义PEP基因油菜超油1号菜籽油毒理性评价

A study on toxicological evaluation of oil from Anti-PEP transgenic rape Chaoyou No.1

为评价转反义PEP基因油菜超油1号菜籽油的食用安全性,对该样品进行了急性毒性试验和致突变试验。结果表明,转反义PEP基因超高油油菜菜籽油属无毒级,无致突变作用。大鼠90d喂养试验结果显示,各试验组大鼠体重、进食量、食物利用率、血常规、脏体比及病理组织学观察等各项指标与阴性对照均无显著性差异,无作用剂量为10.0m l/kg体重。

In order to evaluate the food safety of anti - PEP transgenie rape Chaoyou No. 1, acute toxieity and mutagenesis experiments were conducted. Results showed that the oil made from Chaoyou No. 1 ranked as nontoxic class and no mutagenesis action was found. In a 90 - day feeding test with rats, no marked differences in appearanee, body weight, food intake, feed utilization rate, organ relative weight and hemogram of rates were observed between all treated groups and the control, and no pathological changes found in organs such as liver and kindney, with none effect dosage being 10.0ml/kg.