妇科恶性肿瘤NK活性的初步研究

A PRELIMINARY STUDY OH NATURAL KILLER ACTIVITY IN GYNOCOLOGICAL MALIGNANCIES

本文应用^(125)IUdR标记K562作为靶细胞,测定42例正常妇女、22例妇科良性肿瘤及28例妇科恶性肿瘤外周血单个核细胞的自然杀伤(NK)活性。妇科恶性肿瘤患者NK活性明显低于正常妇女及妇科良性肿瘤患者,表明妇癌患者NK活性低下。妇癌患者中,卵巢恶性肿瘤患者NK活性明显低于宫颈癌患者,差异有显著性意义。本文初步将4例妇科恶性肿瘤患者外周血单个核细胞用白细胞干扰素进行处理,结果NK活性明显升高并接近正常水平。可望该方法能成为妇科恶性肿瘤免疫治疗的新途径。

A release assay of ^(125)IUdR labelled K562 cells as target cells was performed for measuring natural killer(NK)activity of mononuclear cells inthe peripheral blood of 92 cases, including 42 healthy women, 22 patients with gyne cological benign tumors and 28 patients with gynocological malignancies. The NKactivity of malignant tumor group was obviously lower than those of healthy womenand of benign tumor group, it suggested that a defective NK activity was presentedin the patients with gynecological malignancies. The NK activity in the patientswith ovarian malignant tumors was much lower than in the patients with cervicalcancer, statistically the difference was of significance. In this study the leuco-cyte interferon was studied for its effects on the NK activity of peripheralblood mononuclear cells from 4 cases with gynecological malignancies. the levelof NK activity augmented significantly in every case near to the nomallevel. The Augmentation of NK activity by interferon may be used for im-munothpy of gynecological malignancies.