期刊文献+

单肺麻醉期间气管分泌物细胞间黏附分子-1的表达 被引量:2

下载PDF
导出
摘要 目的:研究双肺通气与单肺通气麻醉期间气管分泌物中细胞间黏附分子-1(ICAM-1)的表达。方法:将20例肺癌手术病人,分为单腔导管插管双肺通气麻醉(I组)和双腔导管插管单肺通气麻醉(组)两组,分别于麻醉前(T0)、手术前(T1)、麻醉后100min(T2)、麻醉结束时(T3)采集I组气管分泌物及组非通气侧的气管分泌物;采用酶联免疫吸附法(ELISA)检测气管内分泌物的ICAM-1浓度。结果:两组麻醉后100min及麻醉结束时ICAM-1表达均比麻醉前明显增高,组于麻醉结束时明显高于I组。结论:麻醉、手术牵张、缺氧可导致ICAM-1表达明显上调。
出处 《广西医科大学学报》 CAS 北大核心 2005年第4期525-526,共2页 Journal of Guangxi Medical University
  • 相关文献

参考文献8

  • 1Shi HZ, Xiao CQ, Zhong D, et al. Effect of inhaled interleukin-5 on airway hypereactivity and eosinophilia in asthmatics. Am J Respir Cirt Care Med, 1998, 157(1):204-209.
  • 2Leung KH. Release of soluble ICAM-1 from human lung fibroblasts ,aortic smooth muclecells,dermal microvascular endothelial cells, bronchial epithelial cells, and keratinocytes. Biochem-Biophys-Res-Commun, 1999,14:260(3):734-739.
  • 3Wang Q, Doerschuk CM. The p38 mitogen-activated protein kinase mediates cytoskeletal remodeling in pulmonary microvascular endothelial cells upon intracellular adhesion molecule-1 ligation. J Immunol,2001,166(11):6877-6884.
  • 4Beck-Schimmer N,Schimmer RC,Madjdpour C,et al.Hypoxia mediates increased neutrophil and macrophage adhesiveness to alveolar epithelial cells. Am J Respir Cell Mol Biol, 2001,25(6):780-787.
  • 5McHale JF,Harari OA,Marshall D,et al. TNF a and IL1 sequentially induce endothelial ICAM-1 and VCAM-1expression in MRL/1pr lupus-prone mice. J Immunol,1999,163(7):3993-4000.
  • 6Stichit H, Auer M, Schmitt B, el al. Structure and activity of a chimeric interleukin-8-melanoma-growth stimulatory-activity protein. Eur J Biochem, 1996, 235(1-2):26-35.
  • 7Peter C,Rimensberger MD,Ludwik MD,et al. Attenuation of ventilator induced acute lung injury in an animal model by inhibition of neutrophil adhesion by leumedins(NPC15669). Critical Care Medicine, 1998,26(3):548-555.
  • 8Zhang H,Grasso S,Downney G,et al. Mechanical ventilation activates polymorphonuclear ( PMN ) cells (Abstract). Am J Respir Crit Care Med, 2000, 161:A211.

同被引文献8

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部