文拉法辛治疗抑郁与焦虑性障碍的临床观察

Clinical Observation of Venlafaxine in the Treatment of Depression and Anxiety

目的验证文拉法辛治疗抑郁及焦虑障碍的疗效和不良反应。方法对36例抑郁性障碍、43例焦虑性障碍病人予文拉法辛治疗6周。治疗前、治疗后第4周及第6周用HAMD、HAMA和TEss量表评定,用t检验(治疗前后自身对照)进行统计分析。结果治疗6周后,总有效率为88%,副作用少且轻微。结论文拉法辛治疗抑郁及焦虑性障碍有较好的疗效,且有良好的安全性。

Objective To evaluate the efficacy of venlafaxine in the treatment of depression and anxiety. Methods 36 cases of depressive disorders and 43 cases of anxiety disorders were treated with venlafaxine for six weeks. The HAMD, HAMA and TESS were used to evaluate symptoms before and after treatment 4 and 6 weeks. The results were treated statistically.with t-test （self contrast before and after treatment）. Results Among the 79 patients who completed the 6-weeks treatment,the rate of improvement was 88%. Only little and mild adverse effects was observed. Conclusions The result suggested that venlafaxine is effective in the treatment of depressive and anxiety disorders with mild side effects.