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C-jun氨基末端激酶与缺血性脑损伤

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摘要 丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)信号通路之一c-Jun 氨基末端激酶(c-Jun amino-terminal kinase,JNK)是广泛存在神经细胞中的一条信号转导途径,由一组级联活化的丝/苏氨酸蛋白激酶组成,对于细胞凋亡有重要调控作用。文章对JNK在脑缺血性损伤中的激活作用作简要介绍。
作者 周桃峰 吴家幂
机构地区 安徽省芜湖市弋矶山医院神经内科
出处 《神经疾病与精神卫生》 2005年第3期232-234,共3页 Journal of Neuroscience and Mental Health
关键词 JNK 脑缺血性损伤 细胞凋亡
分类号 R743 [医药卫生—神经病学与精神病学]
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参考文献17

  • 1柴三葆,刘乃奎,唐朝枢.丝裂素活化蛋白激酶磷酸酶[J].国外医学（生理病理科学与临床分册）,2000,20(3):180-183. 被引量：2
  • 2Schaeffer HJ. Mitogen activated protein kinases[J]. Mol Cell Biol, 1999,19: 2 435.
  • 3Kuan CY, Whitmarsh AJ, Yang DD, et al. A critical role of neural- specific JNK3 for ischemic apoptosis[J]. Proc Natl Acad Sci U S A,2003,100(25):15 184-15 189.
  • 4Gupta S, Barrett T, Whitmarsh A, et al. Selective interaction of JNK protein kinase is forms with transcription factors[J].EMBOJ,1996,15:2 760-2 770.
  • 5Claire R, Roger J. The JNK signaling transduction pathway[J]. Mol Cell Biol,1998,18(7) :431-436.
  • 6Widmann C, Gibson S, Jarpe MB, et al. Mitogen-activated protein kinase:Conservation of a three-kinase module from yeast to human[J]. Physiol Rev, 1999,79(1): 143- 180.
  • 7Davis R J. Signal transduction by the JNK group of MAP kinases[J]. Cell, 2000,103 : 239- 252.
  • 8Dong C,Davis RJ, Flavell RA. Signalling by the JNK group ofMAP kinases2c2J un N2terminal kinase[J]. J Clin Immunol,2001,21 (4) :253-257.
  • 9Toshiyuki Suginol,Kazuhiko Nozakil,Yasushi Takagil,et al.Activation of Mitogen-Activated Protein Kinases after Transient Forebrain Ischemia in Gerbil Hippocampus[J]. The Journal of Neuroscience,15,2000,20(12) :4 506-4 514.
  • 10Lennmyr F,Karlsson S, Gerwins P,et al. Activation of mitogen-activated protein kinases in e xperimental cerebral ischemia[J]. Acta Neurol Scand, 2002,106 (6): 333- 340.

二级参考文献12

  • 1Wang W Y, Li M T, Pi R B, et al. Protective action of caffeine on LY294002-induced apoptosis in cerebellar granule neurons[J]. Aeta Pharm Sini, 2000, 21 (1) : 35.
  • 2Li M T, Wang W Y, Sun J, et al. An inhibitor of p38 MAPK prevents apoptosis of cultured cerebellar granule neurons via inhibiting the activity of JNK[J] .中山医科大学学报, 2001, 22(3): 165.
  • 3Watson A, Eilers A, Lallemand D, et al. Phosphorylation of c-Jun is necessary for apoptosis induced by survival signal withdrawal in cerebellar granule neurons[J].J Neurosci , 1998, 18(2):751.
  • 4Schroeter H, Spencer J P, Rice-Evans C, et al.Flavonoids protect neurons from oxidized low-densitylipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3[J]. Biochem J, 2001,358(Pt 3):547.
  • 5Eilers A, Whitfield J, Shah B, et al. Direct inhibition of c-Jun N-terminal kinase in sympathetic neurones prevents c-jun promoter activation and NGF withdrawal-induced death[J]. J Neurochem, 2001,76(5): 1439.
  • 6Le-Niculescu H, Bonfoco E, Kasuya Y, et al. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death[J]. Mol Cell Biol , 1999, 19(1 ): 751.
  • 7Bennett B L, Sasaki D T, Murray B W, et al.SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase[J]. Proc Natl Acad Sci USA, 2001,98(24): 13681.
  • 8Anderson A J, Su J H, Cotman C W. DNA damage and apoptosis in Alzheimer' s disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay[J]. J Neurosci, 1996, 16(5): 1710.
  • 9Luo Y, Umegaki H, Wang X, et al. Dopamine induces apoptosis through an oxidation-involved SAPK/J'NK activation pathway[J]. J Biol Chem, 1998, 273(6): 3756.
  • 10Maroney A C, Glicksman M A, Basma A N, et al. Motoneuron apoptosis is blocked by CEP-1347 (KT 7515 ), anovel inhibitor of the JNK signaling pathway[J] . J Neurosci, 1998, 18(1): 104.

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神经疾病与精神卫生
2005年 第3期

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