致康胶囊复合液灌肠联合结肠镜局部喷注治疗溃疡性结肠炎患者52例

Treatment of Ulcerative Colitis by Combined Therapy of Retention Enema and Per-colonoscopic Spraying with Zhikang Capsule Compound Liquid

目的探讨致康胶囊复合液保留灌肠联合结肠镜局部喷注治疗溃疡性结肠炎(UC)的效果。方法将UC患者86例,分为两组治疗。治疗组(52例)在第1、3个疗程前应用结肠镜局部喷注复合液A(由生理盐水、致康胶囊、庆大霉素、地塞米松配制而成)加思密达各1次,第1个疗程用复合液A加思密达,第2个疗程用复合液A,第3、4个疗程用复合液B(由生理盐水、致康胶囊、庆大霉素配制而成),每晚保留灌肠,每个疗程15天,治疗4个疗程。对照组(34例)应用柳氮磺胺吡啶口服治疗。结果治疗组52例,完全缓解32例,有效15例,无效5例,总有效率90.4%;对照组34例,完全缓解8例,有效14例,无效12例,总有效率64.7%。两组疗效比较差异有显著性(P<0.01)。在临床症状及结肠镜检查方面治疗组也优于对照组。结论致康胶囊复合液保留灌肠联合结肠镜局部喷注治疗溃疡性结肠炎(UC)的疗效较好。

Objective To explore the therapeutic efficacy of patients with ulcerative colitis （UC） treated by retention enema and per-colonoscopic spraying of Zhikang Compound Liquid （ZKCL）, Methods Eighty-six patients with UC were divided into two groups, The 52 patients in the treated group were treated for 4 courses of retention enema, the drug for enema used in the 1st course was ZKCL-A （consisted of normal saline, Zhikang capsule, gentamycin and dexamethasone） and smecta, in the 2nd course ZKCL-A alone, in the 3rd and 4th course, ZKCL-B （with the same contents of ZKCL-A but without dexamethasone）, the enema was carried out once a day in the evening, 15 days as one course. Besides, local spraying of ZKCL-A and smecta were given once by colonoscopy before the 1st and 3rd course. The 34 patients in the control group were treated by salicylazosulfapyridine orally. Results In the treated group, 32 patients got complete remitted, 15 were treated effectively, 5 ineffectively, the total effective rate being 90.38 %, while the corresponding number in the control group were 8, 14,12,and 64.71%, respectively. Significant difference was seen when compared with the therapeutic effects of the two groups. Conclusion Good efficacy was got in treating patients with UC by retention enema and per-colonoscopic spraying with ZKCL