血清尿酸水平和甘油三酯关系的人群研究

Association between serum uric acid and triglyceride in a Chinese community

目的探讨我国人群中血清尿酸水平和甘油三酯(TG)的关系。方法1999年在北京市自然人群中采用分层随机抽样的方法进行横断面调查。本研究对1239例资料完整者进行了分析。结果在男女两性中,高TG血症患病率随血清尿酸水平的升高呈明显的升高趋势。用分层的方法分别校正体重指数、HOMA指数和饮酒后,发现在同一体重指数水平、HOMA指数水平和饮酒水平的人群中高TG血症患病率均随尿酸水平的升高呈明显的升高趋势。采用logistic回归模型校正了年龄、性别、吸烟、饮酒、体重指数、HOMA指数和总胆固醇等因素后,以尿酸四分位最低层为对照,在尿酸第二、三、四分位层时患高TG血症的OR值分别为1·26(P=0·28)、1·88(P=0·002)、3·36(P<0·001)。结论血清尿酸水平与TG相关,且独立于年龄、肥胖、饮酒和胰岛素抵抗等因素。

Objective To Study the association between the level of serum uric acid and triglyceride in a Chinese population. Methods In 1999, a cross-sectional study was carried out in a natural population of Beijing, using stratified-random sampling method. Serum uric acid and triglyceride were measured in 1239 subjects. Results The prevalence of hypertriglyceridemia significantly increased with increased level of serum uric acid among beth the men and women. After adjusting BMI, HOMA index and alcohol consumption level with stratified methods, the incidence of hypertriglyceridemia increased with increasing level of basal serum uric acid in different levels of BMI, HOMA index and alcohol consumption. After adjusting gender, age, BMI, HOMA index, total cholesterol, smoking and alcohol consumption, the results of multivariate logistic regression analyses indicated that the odds ratio for hypertriglyceridemia as compared with the lowest quartile of serum uric acid was 1.26 （ P = 0. 28 ） for the second quartile, 1.88 （ P = 0. 002） for the third quartile, and 3. 36 （ P 〈 0. 001 ） for the highest quartile. Conclusions Serum uric acid level was strongly associated with triglyceride independent of age, genders, smoking, alcohol consumption, obesity and insulin resistance.