内因性失眠症患者中枢抑制源GABA震荡的脑电涨落变化

The GABA Changes of Encephalofluetuograph in Intrinsic Insomniacs

目的:观察30例失眠人群,中枢神经系统γ-氨基丁酸(GABA)及谷氨酸(Glu)测定值变化,探讨GABA及Glu在内因性失眠人群发病中的作用机制,为临床防治提供依据。方法:采用脑电超慢涨落技术对30例内因性失眠患者及30名对照组分别检测中枢神经递质分布变化。结果:观察对象中16例中枢神经递质分布图提示S1GABA明显降低(P值为0·0031),Glu明显升高(P值为0·0016)。结论:通过脑电超慢涨落分析,发现内因性失眠症患者中枢重要的抑制性神经递质GABA显著降低及Glu明显升高,导致睡眠觉醒周期自主调节紊乱。

Ahn： To investigate the mechanism of γ-aminobutyric acid（GABA） and glutamic acid（Glu） on insomnia , we have deteceted the changes of GABA and Glu in the CNS of 30 instrinsic insomniacs. Methods： To deteceted the changes of transmitter in the CNS of 30 instrinsic insomniacs and 30 controls by encephalofluctuography technology. Results： 16 charts of distributing of centre nerve transmitter of observed objects showed that S1 GABA decreased obviously（ P = 0.0031 ）, and Glu increased obviously （ P = 0.0016）, Conclusion： By encephalofluctuograph technology （ ET）, we found that the most important transmitters-GABA and Glu changed markedly in the intrinsic insomniacs, which induce the turbulence of sleep-wakefulness cycle.