慢性淋巴细胞性甲状腺炎的细胞学表现与甲状腺功能检测研究

The relationship between cytological findings and function of thyroid in chronic lymphocytic thyroiditis

目的探讨慢性淋巴细胞性甲状腺炎(CLT)的细胞学表现与甲状腺功能以及与抗甲状腺抗体的相互关系。方法收集2001年6月至2004年5月在我院内分泌门诊就诊和病房住院治疗的CLT患者的细针吸取细胞学资料以及甲状腺功能结果、抗甲状腺抗体结果并进行统计分析,并且也对CLT的发病年龄、临床体征等进行分析。结果80 例CLT中75例得到甲状腺功能结果,其中52例为甲状腺功能减退(甲减)或亚临床甲减;获得54例抗甲状腺抗体结果, 抗体总阳性率为77.8%。统计分析表明淋巴细胞浸润程度、嗜酸性滤泡细胞(Hurthle细胞)数量和异形程度与甲状腺功能异常有明显相关性,但与抗体水平无相关性。结论甲状腺功能测定对CLT病人来说必不可少,但细胞学表现对慢性淋巴细胞性甲状腺炎具有重要诊断价值。

Objective To investigate the relationship between the cytological findings and function of thyroid,thyroid antibodies in chronic lymphocytic thyroiditis. Methods Fine - needle aspiration cytology （FNAC） specimens of 80 patients with chronic lymphocytic thyroiditis were reviewed and evaluated;thyroid function and thyroid antibodies were measured by radioimmunoassay （RIA）. Additionally,patient＇s age and clinical symptoms were analyzed. Results Function of thyroid was examined in 75 patients from 80 chronic lymphocytic thyroiditis patients. 52 patients had hypothyroidism or sub - clinic hypothyroidism. Among the 80 patients ,thyroid antibodies were examined in 54 patients and the total positive ratio was 77.8%. From statistical analysis, there was significant relationship between lymphocytic infiltration, number and heteromorphism of Hurthle cells and function of thyroid;however,there was no significant relationship between function of thyroid and thyroid antibody. Conclusion Determination the function of thyroid provides a useful diagnosis in patients with chronic lymphocytic thyroiditis. However,the results of the current study demonstrated that cytology maybe is a more reliable and accurate technique to diagnose chronic lymphocytic thyroiditis.