期刊文献+

噻唑烷二酮类药物在保护2型粮尿病患者β细胞功能中的潜在作用 被引量:1

下载PDF
导出
摘要 噻唑烷二酮类药物(TZD)除具有减轻胰岛素抵抗的作用外,还可对胰腺β细胞产生直接的益处,能促进β细胞存活和β颗粒再形成,维持β细胞数量及减少胰岛淀粉样沉积,并参与细胞增殖、分化及炎性反应。由于TZD 对β细胞数量和功能均发挥明显的保护作用,因而该药的早期干预对延缓β细胞衰竭及降低心血管疾病危险,显示巨大的潜力。
作者 赵立 彭永德
出处 《世界临床药物》 CAS 2005年第9期563-567,共5页 World Clinical Drug
  • 相关文献

参考文献6

  • 1M. Dubois,F. Pattou,J. Kerr-Conte,V. Gmyr,B. Vandewalle,P. Desreumaux,J. Auwerx,K. Schoonjans,J. Lefebvre. Expression of peroxisome proliferator-activated receptor γ (PPARγ) in normal human pancreatic islet cells[J] 2000,Diabetologia(9):1165~1169
  • 2L. Mykk?nen,D. J. Zaccaro,C. N. Hales,A. Festa,S. M. Haffner. The relation of proinsulin and insulin to insulin sensitivity and acute insulin response in subjects with newly diagnosed Type II diabetes: the Insulin Resistance Atherosclerosis Study[J] 1999,Diabetologia(9):1060~1066
  • 3J. D. McGarry,R. L. Dobbins. Fatty acids, lipotoxicity and insulin secretion[J] 1999,Diabetologia(2):128~138
  • 4S. M. Haffner,C. Gonzalez,L. Mykk?nen,M. Stern. Total immunoreactive proinsulin, immunoreactive insulin and specific insulin in relation to conversion to NIDDM: the Mexico City Diabetes Study[J] 1997,Diabetologia(7):830~837
  • 5Dr. K. Masuda,Y. Okamoto,Y. Tsuura,S. Kato,T. Miura,K. Tsuda,H. Horikoshi,H. Ishida,Y. Seino. Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide[J] 1995,Diabetologia(1):24~30
  • 6Dr. W. K. Ward,E. C. LaCava,T. L. Paquette,J. C. Beard,B. J. Wallum,D. Porte. Disproportionate elevation of immunoreactive proinsulin in Type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance[J] 1987,Diabetologia(9):698~702

同被引文献23

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部