正常糖耐量与伴2型糖尿病的高血压患者胰岛功能及胰岛素抵抗指数的观察

Observation of islet β-cell function and insulin resistance index of the patients in hypertension with normal glucose tolerance or type 2-diabetes

目的:对比研究正常糖耐量(NGT)的高血压患者及初诊2型糖尿病(T2DM)的高血压患者胰岛功能及胰岛素抵抗参数的特点。方法:对42例NGT组(对照组)和60例T2DM组高血压患者测量血压、体重指数、空腹血糖(FPG)、空腹胰岛素(FINS)等参数,计算胰岛素敏感指数(ISI)、胰岛素抵抗指数(IR)和胰岛素分泌指数(HBCI、FBCI),两组间进行统计学比较。结果:T2DM组的BMI、舒张压(DBP)、FPG、IR较NGT组患者高,ISI、HBCI、FBCI较NGT组低,有统计学意义;T2DM组的年龄、收缩压、空腹胰岛素有高于NGT组的趋势,无统计学意义。结论:T2DM组较NGT组有更高的胰岛素抵抗,同时胰岛素敏感性和胰岛β细胞功能下降;在临床上T2DM患者体重较重,舒张压较高。

Objective： To study the status of islet β-cell function and insulin resistance index of the patients in hypertension with normal glucose tolerance （NGT） and preliminary diagnosed type 2-diabete （T2DM）. Methods： 42 cases with NGT and 60 cases in hypertension with T2DM were observed. Their blood pressure（BP）,body mass index（BMI）, fasting plasma glucose（FPG） and fasting plasma insulin（FINS） were detected. On the basic of FPG and FINS,insulin secretion function （including Homa β-cell function index-HBCI and fasting β-cell function index-FBCI） and insulin resistance level （including Homa model insulin resistance index-IR and insulin sensitivity index-ISI） were calculated. Some compares in statistics were done between the two groups. Results ： The BMI, diastolic blood pressure （DBP）, FPG and IR in T2DM group were higher or stronger than those in NGT group;The HBCI,FBCI and ISI in T2DM group were lower than those in NGT group. The age, systolic blood pressure （SBP）,FINS in T2DM group had higher trend than those in NGT group. Conclusion ： T2DM group has more insulin resistance level, sensitivity of insulin and islet β-cell function decrease than those in NGT group. The weight is heavier and DBP is higher in T2DM group than those in NGT group in clinic.