拓朴异构酶与卵巢癌耐药关系的研究进展

Research progress on relationship between topoisomerace and ovarian cancer

拓朴异构酶(Topoisomerace,TOPO)是参与DNA调整、转录、复制、修复的重要工具酶。TOPO蛋白的含量、活性、功能改变与卵巢癌耐药发生有重要的关系,其作用于相关信号传导通路的上游。TOPO-Ⅱ表达增高的卵巢癌预后较差,而TOPO-Ⅱ抑制剂可提高卵巢癌的化疗效果。

Topoisomerace （TOPO） is the important tool enzyme with the attendance of regulation,transcription,replication and repair of DNA. The content ,activity and function change of TOPO present the important relation to the occur of drug-resistance of ovarian cancer. The high TOPO- Ⅱ expression of ovarian cancer predict the wose results. However,the inhibitor of TOPO- Ⅱ may improve the chemotherapy effect of ovarian cancer.