外阴癌的预后因素分析

Analysis of prognostic factors of vulvar carcinoma.

应用流式细胞术检测了31例外阴鳞癌的DNA含量、细胞增殖活力及ras癌基因表达产物P^(21),并结合临床病理因素,分析了38例外阴鳞癌的预后影响因素。经Cox举因素分析及Kaplan—Meier生存率曲线比较,临床分期、淋巴结转移、肿瘤的直径、肿瘤细胞核的DNA含量及组织病理分组是外阴癌的预后影响因素;经Cox多因素分析,认为临床分期是最重要的影响因素。提示临床上应重视对肿瘤的临床病理因素的分析。

Objective: To study the effects of clinicopathologic factors of 38 cases vulvar carcinoma on their prognosis,Design: DNA content, cell proliferation and rasp^(21) of 31 cases vulvar carcinoma and clinicopathologic factors of 38 cases vulvar carcinoma were studied using flow cytometry,Cox regression analysis and Kaplan—Meier survival curves. Results: Prognostic factors of vulvar carcinoma were: FIGO stage (OR=4.21, P0.001),lymphatic metastases (OR=3.83, P=0.01),tumor size (OR=1.35, P=0.015), DNA content (OR =436. 6, P=0.02), histopathologic degree (OR=2.27, P=0.023). Conelusion: FIGO stage was the most important prognostic factor of vulvar carcinoma.