芦荟对小鼠便秘的作用及其机制初探

The curative effect of aloe on constipation and its primary mechanism

目的观察芦荟对便秘小鼠的通便作用和对小鼠肠蠕动和肠壁重吸收水分功能的影响。方法通过给小鼠灌服复方地芬诺酯混悬液建立小鼠便秘模型。采用观察首次排红便的时间、粪便的性状、干重量以及小鼠肠推动的推进百分率,来判断芦荟治疗便秘的作用,并探讨其对小鼠肠蠕动和肠壁重吸收水分功能的影响。结果高或中浓度用药组小鼠首便时间为(200.8±19.4)min和(229.3±17.5)min,与阴性对照组(253.8±23.2)min比较,均能缩短便秘小鼠的首便时间(P<0.05),且高浓度用药组的效果更为明显(P<0.05);高或中浓度用药组小鼠排便的总干重量为(45.0±8.5)mg和(33.0±9.5)mg,与阴性对照组(16.5±9.3)mg比较,均能增加便秘小鼠排便的总干重量(P<0.05),且高浓度用药组的效果更为明显(P<0.05),而且湿便较多,与阳性对照组(64.5±18.8)mg比较(P<0.05);高、中或低浓度芦荟治疗组小鼠肠蠕动的推进百分率分别为(93.7±4.0)%,(86.5±9.5)%和(80.4±13.4)%,与空白对照组(69.0±8.4)%比较,均能提高便秘小鼠肠蠕动的推进百分率(P<0.05), 其中高浓度组最为明显。结论芦荟能有效加强小鼠肠蠕动和减少肠壁重吸收水分功能,且作用温和,起到治疗便秘的作用。

Objective To observe the curative effect of aloe on constipation and investigate the effects of aloe on peristalsis and water reabsorpfion of the intestine. Methods We observed the time of discharging the first red stool, character and diy weight in the stool and the propulsion rate of intestines in mice after feeding with the fluid of aloe DC constipation model. Results In the high and moderate concentration group, thetime of discharging the first red stool was （200.8 ± 19.4）min and （229.3 ± 7.5）min, which were shorten compared with the negative control group（253.8 ± 23.2）min（ P 〈 0.05）. The high concentration group was of higher effect, The city weight of stool of the high and moderate concentration group were （ 45.0 ±8.5） mg and （33.0 ± 9.5）mg, significantly more compared with the negative control group （ 16.5 ± 9.3）mg（ P 〈 0.05 ）. The number of wet stool increased, compared with positive control group（ P 〈 0.05）. The propulsion rate of the intestines of the high and moderate low concentration group was（ 93.7 ± 4.0） %, （ 86.5 ± 9.5 ） % and （ 80.4 ± 13.4 ） %, signitleantly higher than the control group（69.0 ± 8.4 ） % （ P 〈 0.05 ）. Conclusion Aloe can enhance the peristalsis of small intestine and reduce the reabsorption of water in bowel wall. These effect is mild and can be used for treatment of constipation.