层层静电自组装构建壳聚糖/肝素抗菌多层膜的研究

Construction of Anti-bacterial Multilayer Films via Layer-by-layer Electro Static Self-assembly of Chitosan and Heparin

Chitosan as an antibacterial agent and heparin as an anti-adhesive agent were alternatively deposited onto aminolyzed poly(ethylene terephthalate)(PET) to construct anti-adhesive and antibacterial multilayer films.The contact angle and UV data verified the progressive build-up of the multilayer film by alternate deposition of the polyelectrolytes.PRT experiment and in vitro antibacterial assay indicated that the multilayer-modified PET films had much better hemocompatibility and much stronger antibacterial performance than(unmodified) PET.Such an easy processing and shape-independent method to prepare an anti-adhesive and(antibacterial) surface may have a good potential for surface modification of cardiovascular devices.

Chitosan as an antibacterial agent and heparin as an anti-adhesive agent were alternatively deposited onto aminolyzed poly（ ethylene terephthalate）（PET） to construct anti-adhesive and antibacterial muhilayer films. The contact angle and UV data verified the progressive build-up of the muhilayer film by alternate deposition of the polyelectrolytes. PRT experiment and in vitro antibacterial assay indicated that the muhilayermodified PET films had much better hemocompatibility and much stronger antibacterial performance than unmodified PET. Such an easy processing and shape-independent method to prepare an anti-adhesive and antibacterial surface may have a good potential for surface modification of cardiovascular devices.