局部应用噻吗心安对人眼脉络膜血液循环的影响

EFFECTOFTOPICALTIMOLOLONTHEHUMANCHOROIDALCIRCULA-TION

应用双功彩色多普勒研究了２２名正常人局部应用０．５％噻吗心安眼药水对脉络膜血液循环的影响。用一眼作用药眼，另一眼作自身对照。治疗眼睫状后短动脉血液积分（ＴＡＭＸ）、收缩期峰值血流速度（Ｖｓ）及舒张期末血流速度（Ｖｄ）均显著大于对照眼（Ｐ＜０．０５）；血管阻力明显小于对照眼（Ｐ＜０．０５）；灌注压与血流积分呈线性关系（Ｐ＜０．０５）。作者认为噻吗心安产生脉络膜血流量的增加为两个同时发生的过程所致，即①通过灌注压增加的间接影响；

Theefectoftopicaltimololmaleate0.5%onthechoroidalcirculationwasinvestigat-edin22normalsubjectsusingthecolorDoppler,withoneeyeasthetimolol-treatedeyeandthecontralateraleyeastheauto-controleyeineachindividual.Theresultsshowedthat,ofthe2groupsofeyes,therewasasignificantincreaseintimeaveragemaximumvelocity(TAMX),systolicpeakvelocity(Vs),anddiastolicvelocity(Vd)intimolol-treatedeyes.Theresistanceindexintimolol-treatedeyeswaslowerthaninthecontroleyes(P<0.05).Significantlinearcorrelationinthetimo-lol-treatedeyesfoundbetweenperfusionandTAMX.Itisthoughtthattheincreaseinvolumetricbloodflowratebytimololisduetotwoconcurrentprocesses:1.anindirectefectonthechoroidalcirculationthroughtheincreaseinperfusionpressure;2.adirectefectonchoroidalvesselsresult-ingfromactionofdrugonadrenergicreceptorsthatispresentinthechoroidalvasculature.