摘要
目的:了解增殖性糖尿病视网膜病变(proliferativediabeticretinopathy,PDR)、增殖性玻璃体视网膜病变(proliferativevitreoretinopathy,PVR)、视网膜中央静脉阻塞(centralretinalveinocclusion,CRVO)等患者玻璃体和血清中表皮生长因子(epidermalgrowthfactor,EGF)的水平。方法:放射受体法定量测定患者和正常对照组共67例玻璃体和血清中EGF的含量。结果:患者组玻璃体中EGF含量明显高于对照组(P<0.001),其中以PVR组含量最高;玻璃体切割液EGF水平低于玻璃体原液,反应60%~63%的原液水平,二者呈正相关。对照组和患者组血清中EGF比较,PDR组最高,其次为CRVO组,PVR组低于对照组。结论:EGF可能在这些疾病的病因病理中起一定作用;
PURPOSE:Tomeasuretheepidermalgrowthfactor(EGF)contentsinvitreousandserumsamplesinnormalsubjectsandpatientswithproliferativeretinaldiseases.METHODS:Usingradioreceptorassay(RRA)tomeasuretheEGFcontentsinvitreousandseruminpatientswithpro-liferativediabeticretinopathy(PDR)16cases,proliferativevitreoretinopathy(PVR)20cases,centralretinalveinocclusion(CRVO)16cases,otherretinalvasculardiseases5cases,andcontrols10cases.RESULTS:TheEGFlevelsinvitreousofthepatientgroupwereapparentlyhigherthanthoseofthecontrols(P<0.001).Amongpatientgroup,theEGFcontentsinvitrectomyfluidwaslowerthanthatoforiginalvitreous,reflectingabout60%~63%EGFlevelinoriginalvitreous,bothshowedpositivecorrelation.TocomparetheEGFcontentsinserumofpatientsandcontrols,theEGFcon-tentsinserumofPDRgroupincreasedsignificantly.InCRVOgrouptheEGFcontentsalsoin-creased,whileinPVRgroup,theEGFcontentswerelowerthanthoseofthecontrols.CONCLU-SIONS:TheincreasedEGFcontentsinvitreousofpatientgroupmayplayaroleinthepathogenesisofproliferativeretinaldiseases.TheRRAisasensitivemethodforquantitativemeasurementofgrowthfactor.
出处
《中华眼底病杂志》
CAS
CSCD
1996年第2期91-93,共3页
Chinese Journal of Ocular Fundus Diseases
基金
博士学科点专项科研基金
关键词
视网膜疾病
表皮生长因子
尿抑胃素
RetinaldiseasesEpidermalgrowthfactor-urogastroneRadioimmunoassay