摘要
药物基因组学是一门充满活力并迅速发展的新兴学科,以探讨药物作用的遗传分布,确定药物作用靶点,提高药物效应及安全性为目标,研究影响药物分布、消除等个体差异的基因特性,以及基因变异所致的不同病人对药物的不同反应等。本文综述了药物基因组学在药动学研究中的进展情况,介绍和论述了药物基因组学的概念和研究内容;探讨了药物基因组学在药动学中的应用,药物代谢酶的多态性和药物转运体的多态性;并展望药物基因组学的应用前景。
Pharmacogenomics is a burgeoning discipline and is being developed rapidly. The aim of pharmacogenomics is to investigate the genetic distribution of the drugs, and to determine the targets of the drugs so as to ensure the optimal efficacy and safety in the clinical practices. It is also used to investigate individual gene characteristics which affect distribution and elimination, and patients＇ different response to the drug owing to gene variation is also studied. The advancement of pharmacogenomics in pharmacokinetic study was reviewed in this paper. And the polymorphisms of drug metabolizing enzymes and drug transporters were discussed as well. The prospect of its application was also forecast.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2005年第5期473-476,共4页
Journal of China Pharmaceutical University
关键词
药物基因组学
药动学
代谢酶
转运蛋白
Pharmacogenomics
Pharmacokinetics
Metabolizing enzyme
Transporters
