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恩曲他滨的合成 被引量：8

Synthesis of Emtricitabine
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摘要 水合乙醛酸和l-醇经酯化得到的二羟基乙酸l-基酯,依次与2,5-二噻烷-1,4-二醇、氯化亚砜和硅烷保护的5-氟胞嘧啶反应,最后还原得到HIV逆转录酶抑制剂恩曲他滨,总收率27%。 Emtricitabine was synthesized from l-menthol and glyoxylic acid by esterification, reactions with dithianediol, thionyl, chloride and silylated 5-fluorocytosine followed by reduction. The overall yield was 27 %.
作者 孟静芳 吴雪松 岑均达
机构地区 上海医药工业研究院 上海恒瑞医药有限公司
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2005年第10期589-591,共3页 Chinese Journal of Pharmaceuticals
关键词 恩曲他滨 抗病毒药物 合成 emtricitabine antiviral agents synthesis
分类号 R978.7 [医药卫生—药品]
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参考文献8

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中国医药工业杂志
2005年 第10期

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