摘要
目的:探讨骨桥蛋白(OPN)在人脑胶质瘤中的作用、表达及其意义.方法:采用RTPCR及免疫组化染色方法检测脑胶质瘤组织和正常组织中骨桥蛋白.结果:骨桥蛋白在胶质瘤组织细胞中表达,而在正常脑组织细胞中无表达,而且OPN的表达浓度与胶质瘤恶性程度呈正相关.结论:人脑胶质瘤中OPN的表达与其恶性程度密切相关.
AIM: To investigate the expression of osteopontin in human gliomas as well as its function. METHODS: Osteopontin expression in human normal brain cells and glioma cells was detected by immunohistochemical staining and RT-PCR method. RESULTS: Osteopontin was expressed in glioma cells but was not expressed in human normal brain cells. CONCLUSION: Osteopontin expression in glioma is closely related to the malignant degree of glioma.
出处
《第四军医大学学报》
北大核心
2005年第18期1677-1679,共3页
Journal of the Fourth Military Medical University