神经系统疾病与超氧化物歧化酶

Nervous system diseases and superoxide dismutase

目的:认识国内外有关自由基在脑缺血再灌注、家族性肌萎缩侧索硬化症、帕金森病及阿尔茨海默病上的作用,探讨超氧化物歧化酶在治疗和预防多种神经系统病变发生中的重要意义。资料来源:应用计算机检索Medline1997-01/2004-08与超氧化物歧化酶和神经系统疾病相关的文献,检索词“superoxidedismutase,familialamyotrophiclateralsclerosis,Parkinson’sdisease,Alzheimer’sdisease”,并限定文献语种为English。同时计算机检索万方数据库2002-01/2004-08的相关文献,检索词“超氧化物歧化酶,脑缺血再灌注,家族性肌萎缩侧索硬化症,帕金森病,阿尔茨海默病”,并限定语种为中文。资料选择:就检索到的120余篇文献进行筛选,选择以超氧化物歧化酶和相应神经系统疾病为主要研究内容的文献20多篇,筛除明显无关文献或相关性不强的文献,对剩余文献开始查找全文,进一步明确其相关性。纳入标准:随机对照研究;实验或临床研究包含平行对照组。排除标准:重复性研究和综述类文章。资料提炼:将筛选到的20余篇文献按超氧化物歧化酶和相应神经系统疾病分类:其中6篇与脑缺血再灌注相关,8篇与家族性肌萎缩侧索硬化症相关,5篇与帕金森病相关,7篇与阿尔茨海默病有关。资料综合:20余篇文献共包括650例患者(或实验动物),说明了在多种神经系统疾病中由于体内超氧阴离子自由基水平的增加,引发生物膜的脂质过氧化反应,造成DNA氧损伤,导致多种退行性神经病变的发生,超氧化物歧化酶可以清除超氧阴离子自由基对细胞的这种损害。结论:超氧化物歧化酶作为一种重要的抗氧化酶,在多种神经系统病变的发生中有着重要的意义。

OBJECTIVE： To investigate the significance of superoxide dismutase （SOD） in the treatment and precaution of the occurrence of the nervous system diseases according to the recent studies at home and abroad about the role of free radicals in cerebral ischemia reperfusion, familial amyotrophic lateral sclerosis, Parkinson disease, Alzheimer disease. DATA SOURCES： An online search of Medline database was undertaken by using the keywords of “superoxide dismutase, reperfusion after cerebral ischemia, familial amyotrophic lateral sclerosis, Parkinson disease, Alzheimer disease” to identify the relevant articles published in English from January 1997 to January 2005. Meanwhile, Chinese journals full-text database was scanned with computer to search relevant articles from January 1992 to January 2005, the keywords were “superoxide dismutase, reperfusion after cerebral ischemia, familial amyotrophic lateral sclerosis, Parkinson disease,Alzheimer disease” with language limited to Chinese. STUDY SELECTION： Totally 120 articles were retrieved and screened, and 20 about SOD and nervous system diseases were selected, and then those with obvious indifferent contents or less correlation were excluded, and the full texts of the rest articles were searched to further identify the correlation. Inclusive criteria： randomized control trial; experimental or clinical study with parallel control group. Exclusive criteria： repetitive studies or reviews. STUDY EXTRACTION： The 20 articles were classified according to SOD and nervous system diseases, including 6 articles were correlated with reperfusion after cerebral ischemia, 8 with familial amyotrophic lateral sclerosis, 5 articles with Parkinson disease, and 7 with Alzheimer disease. DATA SYNTHESIS： In the 20 articles, 650 patients or experiment animals were involved, it is significant that many kinds of nervous system diseases were caused by the increase of free radicals of in vivo superoxide anion, which leads to lipid peroxidation of biomembrane and lesion of DNA, and then results in the occurrences of various degenerated peuropathy. SOD can eliminate the damage caused by superoxide anion. CONCLUSION： As an important antioxidase, SOD has significance in the development of various nervous system diseases.