针刺合谷穴脑功能磁共振成像研究

fMRI study of acupuncture at large intestine 4

目的观察针刺合谷穴引发脑内相关区域的变化情况。方法对6名健康右利手年轻被试进行右手合谷穴针刺,同时进行全脑fMRI,对脑内活动区域进行定位。结果针刺合谷时引起双侧感觉/运动区,额中回,颞上回前部,丘脑,额上内侧回,双侧小脑,双侧枕颞交界区,对侧岛叶,扣带回前部,中央后回上部以及同侧顶盖区激活,而降低的区域则分别表现在双侧颞极部,内颞叶区,额下内侧回,额叶眶部,双侧颞中回,双侧扣带回后部,枕叶,双侧中央前回中部,同侧中央前回上部。结论针刺合谷能够引发脑内相关区域的激活和降低,说明fMRI能够为针灸机制的探讨提供帮助。

Objective To study the changes in the human brain when needle was acupunctured at the right LI4 acupoint. Methods Six right handed healthy young Chinese subject were instructed to accept the acupuncture at LI4 while being scanned with a 1.5T MR Siemens scanner. Results Activation was found bilateral in M1/SI, middle frontal gyrus, anterior part of superior temporal gyrus, thalamus, medial superior-frontal gyrus, cerebellum, occipital-temporal association area, contralateral in insular, ACC, SI and ipsilateral SII （BA40/43） ; while deactivation was found bilateral in temporal pole, medial temporal lobe, medial inferior frontal gyrus, orbital gyrus, middle temporal gyrus, PCC, occipital lobe, middle part of postcentral gyrus and ipsilateral superior part of postcentral gyrus. Conclusion Activation and deactivation were found in the human brain which induced by acupuncture at the LI4 suggests that fMRI might be helpful to understand the physiological mechanism of acupuncture.