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基因CT120在胶质瘤中的表达及意义

The Expression and Significance of CT120 Gene in Gliomas
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摘要 目的:研究基因CT120在胶质瘤组织中的表达及其与胶质瘤组织病理学的关系。方法:应用免疫组织化学方法检测50例胶质瘤手术切除标本、3例正常脑组织中CT120蛋白的表达;应用半定量RT-PCR检测20例胶质瘤、3例正常脑组织中CT120mRNA的表达。结果:免疫组织化学检测发现正常脑组织中CT120蛋白无表达,50例胶质瘤组织中CT120蛋白表达阳性率为50.9%,不同级别胶质瘤中的表达无显著差异(χ2=2.99,P>0.05);半定量RT-PCR检测正常脑组织中CT120mRNA呈弱表达,不同病理级别胶质瘤CT120mRNA表达无显著差异(χ2=3.25,P>0.05)。结论:基因120在胶质瘤有表达,但在胶质瘤发生发展中作用不明显。 Objective： To study the expression of CT120 gene in gliomas. Methods： The expression of CT120 protein was detected in 3 normal brain tissues and 50 cases of gliomas using immunohistochemical method. The expression of CT120 mRNA was detected in 3 normal brain tissues and 20 cases of gliomas using RT-PCR semi-quantity method. Results： The expression rate of CT120 protein in cases with normal brain tissues and with gliomas was 0 % and 50.9%, respectively. The difference wasn＇t statistically significant （χ^2=2.99, P〉0.05）. The high expression rate of CT120 protein did not correlate with the pathological grade of gliomas. The expression rate of CT120 mRNA in the three normal brain tissues was low. There was no statistically significant difference among the expression of gliomas with different grades. The high expression rate of CT120 mRNA did not correlate with the pathological grade of gliomas （χ^2=3.25, P〉0.05）. Conclusion： There is the expression of CT120 gene in gliomas, but it doesn＇t play an important role.
作者 石松生 任保刚 杨卫忠 林于峰
机构地区 福建医科大学协和临床学院神经外科
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2005年第19期1109-1111,共3页 Chinese Journal of Clinical Oncology
关键词 CT120 胶质瘤 脑组织 CT120 Glioma Brain tissue
分类号 R739.4 [医药卫生—肿瘤]
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参考文献10

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中国肿瘤临床
2005年 第19期

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