摘要
目的对高分子生物材料壳聚糖在软骨组织工程中的应用现状进行综述。方法广泛查阅近年来有关壳聚糖在组织工程中应用的文献,综合分析,讨论其生物相容性、可降解性及其应用。结果壳聚糖具有良好的生物相容性、可降解性,除能提供细胞生长所需的三维支架作用外,还能提供类似软骨基质的细胞外环境,维持细胞表型及功能。结论壳聚糖在软骨组织工程中具有良好的应用前景。
Objective To introduce the application of polymer material, chitosan, in the cartilage tissue engineering. Methods The recent original articles on the application of chitosan in cartilage tissue engineering were extensively reviewed. The biocompatibility and biodegradation characters of chitosan and its application were analysed. Results Chitosan has a high degree of biocompatibility and a favorable chondrogenic characteristic. It can support the maintenance of the phenotypic morphology of chondrocytes besides being used as a scaffold for cell growth. Conclusion The perspect of the application of chitosan in cartilage tissue engineering is hopeful.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2005年第10期831-834,共4页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家自然科学基金资助项目(30270393)
广东省科技计划资助项目(2003A302102)
关键词
壳聚糖
组织工程软骨
应用
Chitosan
Tissue engineered cartilage
Application
