摘要
类风湿关节炎(RA)是一种常见的全身性自身免疫病,目前尚无特异性诊断及治疗方法,尤其是不典型和特殊类型RA易于误诊误治。近年来,AKA、APF、抗RA33、抗CCP、抗Sa及抗BiP抗体等新型自身抗体的发现提高了RA诊断的敏感性和特异性;核磁共振、CT及超声检查等影像学检查提高了RA关节损害的检出率,这些新的血清学检测指标及影像学检查的应用有助于RA的早期诊断。与此同时,新的DMARDs和生物制剂不断问世,RA的治疗手段不断丰富。已经证实,绝大多数RA患者经过早期、联合、个体化的规范治疗,预后良好。
Rheumatoid arthritis （RA） is a common systemic autoimmune disease. There is neither specific diagnostic nor therapeutic approach for the disease, particularly in atypical and uncommon cases. It has been known that autoantibodies such as AKA, APF, anti-RA33, anti-CCP, anti-Sa and anti-BiP are valuable for the diagnosis of RA. New image techniques are more sensitive than conventional radiography. These serologic markers and image techniques dramatically improve the diagnosis of RA. At the same time, a number of novel biological agents have been clinically used. Studies have suggested that complete remission is achievable in most case with early rational therapy.
出处
《基础医学与临床》
CSCD
北大核心
2005年第9期774-779,共6页
Basic and Clinical Medicine
关键词
类风湿关节炎
诊断
治疗
rheumatoid arthritis
diagnosis
therapy
