β-catenin和c-myc在侵袭性胸腺瘤中的表达及临床意义

Expression and clinical significance of β-catenin and c-myc in invasive thymoma

目的:探讨侵袭性胸腺瘤的生物学特性,以发现判断胸腺瘤良恶性的客观指标。方法:应用-βcaten in和c-myc单克隆抗体对不同分期的胸腺瘤标本做免疫组化染色,分析其表达方式和水平与胸腺瘤分期的相关性,并分析两种分子表达的相关性。结果:随着肿瘤分期的增高,-βcaten in膜表达减少,核表达增多,c-myc表达也逐渐增强。β-caten in的核表达程度与c-myc的表达呈正相关。结论:-βcaten in和c-myc表达方式和水平的差异可反映出胸腺瘤的生物学特性,临床上可尝试做为判断侵袭性胸腺瘤的客观指标。

Objective ： To investigate the biological characteristics of invasive thymoma and to find the objective indicator of benign and malignant thymoma. Methods： β-catenin and c-myc monoclonal antibody was used in the immunohis- tochemical staining of thymoma tissues of different stages. Both the correlation between tbe expressions of β-catenin and c- myc and the relationship between their expressions and stages of thymoma were analyzed. Results： As tbe stage evolved, the nucleus expression of β-catenin and c-myc expression increased, while the membrane expression of β-catenin decreased. There was positive correlation between the nucleus expression of β-catenin and c-myc expression. Conclusion： The style and level of the expression of β-catenin and c-mye can reflect the biological characteristics of thymoma. The expression of β-catenin and c-mye may be used as objective clinical indicators of invasive thymoma.