p19蛋白在神经胶质瘤中的表达

Expression of p19 protein in glioma

目的:探讨p19基因在神经胶质瘤发生、发展中的可能作用.方法:应用免疫组化S-P法,对66例神经胶质瘤中的p19蛋白进行检测,与23例正常脑组织进行对照,分析其在神经胶质瘤中的表达情况,应用卡方检验进行统计学分析.结果:p19蛋白在66例神经胶质瘤中总阳性率为28.79%,在正常脑组织中表达阳性率为60.87%,二者相比差异有统计学意义.p19蛋白表达阳性率在Ⅰ级神经胶质瘤中为57.89%,Ⅱ级中为26.92%,Ⅲ～Ⅳ级中为4.76%.Ⅰ级与Ⅱ级阳性率比较,Ⅰ级与Ⅲ～Ⅳ级阳性率比较,Ⅱ级与Ⅲ～Ⅳ级阳性率比较,差异均有统计学意义.结论:p19基因可能参与了神经胶质瘤的发生发展过程,其检测有可能作为判定神经胶质瘤恶性程度的一个辅助指标.

Objective： To find the role of p19 gene in tile growth and development of glioma. Methods： Immunohistochemical S-P method was used to detect the expression of p19 in 66 glioma and 23 normal brain tissues. Chi square test was used to analyze the difference in the expression of p19 protein. Results： The positive expression rate of p19 was 28.79% in 66 gloima and 60.87% in 23 normal tissues, and it was 57.89% in grade Ⅰ glioma, 26.92% in grade Ⅱ glioma, and 4.76% in grade Ⅲ and Ⅳ glioma. There were significant differences in the positive expression rate of p19 between glioma and normal brain （ P 〈 0. 01 ） , between grade Ⅰ and grade Ⅱ glioma （ P 〈 0. 05） , between grade Ⅱ and grade m and IV glioma （P 〈 0.01）, and between grade Ⅰ and grade Ⅲ and Ⅳ glioma （P 〈 0.05）. Conclusion： p19 gene may involve in the growth and development of glioma, and the detection of p19 protein may help determine the malignant degree of glioma.