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抗癌新药紫杉醇的药剂学研究概况 被引量:5

Pharmaceuticalresearch advance on the novel anti-cancer drug taxol
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摘要 紫杉醇抗癌活性强,是目前抗癌药物的研究热点。本文对已经上市的紫杉醇注射液,以及目前正在开发中的紫杉醇新处方和气剂型如脂质体、静脉乳、毫微囊、植入片等的研究现状发动态进行综述。 axo ,a strong and broad-spectrum anti-cancer agent,possesses a unique mechanism of cytotoxic actio ,mowis the research focused on anti-cancer drugs. In this paper,the current pharmaceutical research and development oftaxol,including iv injections sold in market,the new formulation and dosage forms,such as hposome,iv emulsion,implant disc are reviewed.
出处 《中国医院药学杂志》 CAS CSCD 北大核心 1996年第4期176-178,共3页 Chinese Journal of Hospital Pharmacy
关键词 紫杉醇 抗癌药 药剂学 Taxol,pharmaceutics anti-cancer
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同被引文献23

  • 1王猛,张钧寿,周建平.注射用辅料泊洛沙姆188[J].药学与临床研究,2007,15(1):10-13. 被引量:31
  • 2王亚南,王洪权,窦媛媛.羟丙基-β-环糊精在药剂学中的应用与研究[J].食品与药品,2007,9(04A):47-50. 被引量:18
  • 3阎家麒,童岩,王九一.紫杉醇脂质体的制备及其抑瘤作用的研究[J].药物生物技术,1996,3(3):154-157. 被引量:40
  • 4Dahet CF, Baroody GM, Howland RJ. Effect of a surfactant, Tween 80, on the formation and secretion of chylomierons in the rat[J]. Food Chem Toxicol, 2003, 41 (4) : 575-582.
  • 5[英]R.C.罗[美]P.J.舍斯基,[英]P.J.韦勒编,郑俊民主译.药用辅料手册(原著第四版)[M].北京:化学工业出版社,2005:239.
  • 6Robert G. Strickley. Solubilizing Excipients in Oral and Injectable Formulations [J].Pharmaceutical Research, 2004, 21(2):201-230.
  • 7Mu L, Feng SS. A novel controlled release formulation for the anticaneer drug paclitaxel (Taxol);PLGA nanoparticles containing vitamin E TPGS [J]. J Control Release, 2003,86 (1) : 33-48.
  • 8Mu L, Feng SS. Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol) [J]. Control Release, 2002, 80 (1-3): 129- 144.
  • 9Lundberg BB,Risovic V,Ramaswamy M,et al. A lipophilic paclitaxel derivative incorporated in a lipid emulsion {or parenteral administration [J]. Control Release, 2003, 86 (1) : 93-100.
  • 10张学农,唐丽华,阎雪莹,张强.羟丙基-β-环糊精对紫杉醇的增溶作用及其分子包合机制研究[J].中草药,2007,38(9):1317-1320. 被引量:12

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