洋地黄中毒的血药浓度与临床分析

Serum concentrations of digitalis toxication and clinical analysis

本文对地高辛血药浓度＞２．６ｎｍｏｌ／Ｌ的１４３例次住院患者进行了研究。结果表明：达到潜在中毒、中毒血药浓度的患者，中毒、可疑中毒合并发生率分别为４７％和７４％。绝大多数患者预后良好，中毒病死率为４．７％。对洋地黄反应的个体差异大。最可不的诊断方法是临床动态观察结合血药浓度测定，特征性、多样性心律失常有助于中毒的诊断。

43 hospitalized patients with serum digoxin concentration more then 2. 6nmol/L were studied. The incidenceof definite and possible digitalis were 47% in potential toxic level and 74% in toxic level respectively. Most patientswere of favourable prognosis,the mortality rate of intoxication was 4.7%. The sensitivity to digitalis was variablein diffcrent patients. Clinic ambulatory observation in combination with assay of serum concentration is the bestmethods for digrtalis toxication.