胃液可溶性IL-2R及微生物群与胃癌相关性研究

Relevant Research of Soluble IL-2 Receptor and Microorganism Group in Gastric Fluid with Gastric Cancer

目的:对胃癌患者可溶性白细胞介素2受体(sIL-2R)定量分析及病变部位黏膜微生物检查,探讨其病变局部免疫功能状态及其可能相关因素,为临床诊断胃癌提供依据。方法:收集91例胃病患者病变部位的胃液及胃黏膜活组织,进行微生物分离培养鉴定,胃液sIL-2R及微生物群的检测。结果:胃癌患者胃液sIL-2R水平非常显著高于对照组,胃液微生物群检出葡萄球菌、白色念珠菌、四联球菌、八迭球菌、不解乳真杆菌、产气真杆菌、产亚硝酸真杆菌等。结论:胃癌患者sIL-2R水平与胃部疾病的严重程度密切相关。并提示胃癌患者胃黏膜局部的T细胞免疫受阻,微生物检出率高使胃内氮亚硝基化合物(NOC)合成进一步增加,从而促进胃癌的发生。

Objective： To investigate local immunity function and impossibly relevant factors of gastric cancer through quantitative analysis of soluble interleukin-2 receptor （sIL-2R） in patients and microorganism examination of lesion mucosa, which can also provide valuable data for clinical diagnosis of gastric cancer. Methods： In 91 cases with gastric disease ,gastric fluid and lesion of gastric mucosa were collected. Then microorganisms and sIL-2R microorganism group of gastric fluid were idendified by separating culture. Results：The level of sIL-2R in gastric fluid of gastric cancer is remarkably higher than contrast group. In gastric fluid Staphylococcus, Candida albicans, Tetrad, Sarcina, some eubacteria are examined. Conclnsions：The sIL-2R level of gastric cancer is closely related to severe extent of gastric disease. It suggests that T cells immunity be blocked in local gastric mucosa of gastric cancer. The high examination rate of microorganism make further increase of nitrogen orthonitral compound （NOC） production in stomach which promote genesis of gastric cancer.