静脉注射右旋糖酐铁治疗腹透患者肾性贫血的应用价值

Clinical Observation of Intravenous Infusion of Iron Dextran in Treatment of Anemia in Peritoneal Dialysis Patients

目的:观察静脉注射右旋糖酐氢氧化铁治疗连续性不卧床腹膜透析(CAPD)的慢性肾衰患者铁缺乏的有效性与安全性。方法:采用静脉注射右旋糖酐氢氧化铁和琥珀酸亚铁口服补铁,观察血红蛋白(Hb),红细胞压积(Hct),血清铁蛋白(SF),转铁蛋白饱和度(TS)及肝肾功能、电解质的变化。结果:静脉注射右旋糖酐氢氧化铁可以显著提高CAPD患者的Hb,Hct,TS,SF,效果优于口服琥珀酸亚铁组,无明显副作用。结论:静脉注射右旋糖酐氢氧化铁治疗CAPD患者铁缺乏,改善肾性贫血安全有效。

Objective：To observe the effects of intravenous iron dextrin in treatment of renal anemia in continuous peritoneal dialysis patients. Methods ：The patients were given intravenous infusion iron （iron dextrin ,namely Cosmofer） and oral iron （ferrous succinate, namely Sulifei ）. During the treatment, Hemoglobin （Hb）, Hematocrit （Hct）, Serum Ferritin （SF） ,Trasferrin Saturation （TS）,liver and renal function and electrolyte were monitored. Results：Ali of the variables were significantly increased in intravenous iron patients than in oral iron patients ,no side-effct. Conclusion：Intravenous infusion of iron dextrin is safe and effective on correction of iron deficiency and improvement of renal anemia.