CA125和TSGF联合检测在妇科肿瘤诊断中的应用价值

Practical value of combined detection of CA125 and TSGF in gynecological tumors.

目的探讨联合检测血清CA125和肿瘤相关物质群(TSGF)的含量对妇科恶性肿瘤的诊断及疗效监测的应用价值。方法妇科恶性肿瘤患者223例、妇科良性肿瘤患者90例及正常对照98人的血清样品,分别用电化学发光免疫测定法和化学比色定量法测定CA125和TSGF含量,然后进行分析。结果与良性肿瘤组和健康体检组相比,妇科恶性肿瘤患者血清CA125和TSGF的含量明显升高(P<0.01),CA125和TSGF测定对妇科恶性肿瘤的敏感度分别是58.3%和72.2%,特异度分别是91.0%和90.4%。二者联合检测的敏感度和特异度分别为79.4%和82.4%。妇科恶性肿瘤患者血清CA125和TSGF含量在治疗后与治疗前相比,有显著差异(P<0.05)。结论血清CA125和TSGF检测对妇科肿瘤良恶性的辅助诊断及鉴别诊断具有一定应用价值,联合检测不仅可以提高妇科恶性肿瘤的阳性诊断率,对妇科恶性肿瘤的疗效观察和术后监测也具有一定价值。

Objective To study the practical value of combined detection of the serum levels of CA125 and tumor supplied group of factors （ TSGF） in the diagnosis of malignant gynecological tumors and the observation of the curative effect. Methods Serum levels of CA125 and TSGF in 223 patients with malignant gynecological tumor, 90 patients with benign gynecological tumors and 98 normal controls were measured by elctrochemiluminescence immuno - assay （ECLIA） and chemical colorimetry. Results The levels of CA125 and TSGF in the group of malignant gynecological tumor were significantly higher than those in benign gynecological tumors and normal control group （P 〈 0. 01）. Sensitivities of determination of CA125 and TSGF were 58.3% and 72.2% and the specificity were 91.0% and 90.4%. Sensitivity and specificity of combined detection of two kinds tumor markers were 79.4% and 82.4%. The levels of CA125 and TSGF in patients with malignant gynecological tumors were significantly different after treatment （P 〈 0.05）. Conclusion The determination of CA125 and TSGF are helpful in diagnosis and in differential diagnosis of gynecological tumors . Combined detection of two kinds of serum tumor makers not only increases the detective positive rate but also is valuable to observe the curative rate and postoperative monitor of the malignant gynecological tumors.