摘要
目的:介绍近年来口服结肠定位给药方法药剂学方面的研究进展。方法:分析有关文献资料,对结肠的生理特点,口服结肠给药系统的原理和常用材料进行归纳和总结。结果:有多种药剂学方法可实现结肠给药的目的,目前主要应用的方法有时间依赖型、pH依赖型、酶解型等系统。结论:口服结肠定位给药系统作为现代药物剂型的高新技术之一,有重要的科研价值和市场前景。
Objective: To introduce the progress of research on the pharmaceutical approaches to oral colon-specific drug delivery system in recent years. Methods: Literatures were collected and analyzed on the characteristics of the colon, the principle and the materials of the oral colon-specific drug delivery system. Results: There were various of pharmaceutical approaches used on colonic delivery, such as time-based, pH-dependent and biodegradable systems, etc. Conclusion: As one of the advanced technologies of modern pharmaceutical methods, oral colon-specific drug delivery system plays an important role in the targeted drug research and has a good commercial prospect.
出处
《药学服务与研究》
CAS
CSCD
2005年第3期254-258,共5页
Pharmaceutical Care and Research
关键词
结肠定位
PH依赖
生物降解
时间依赖
综述
colon-specific delivery
pH-dependent
biodegradation
time-dependent
review