内皮抑素在肺癌患者血清中的表达

Serum Endostatin Levels in Patients with Primary Lung Cancer

目的:研究肺癌患者外周血清中内皮抑素的含量与肺癌临床和病理生理特征的关系。方法:采用ELISA法检测70例原发肺癌与20例健康人血清中内皮抑素的含量。结果:血清内皮抑素含量在肺癌及健康人分别为(105.14±32.59)ng·ml-1和(55.56±19.78)ng·ml-1,P<0.01;血清内皮抑素含量与肺癌原发肿瘤的大小、有无远处转移、细胞分化程度及临床分期密切相关(P<0.05),与性别、年龄、组织学类型及淋巴结转移无显著相关。结论:肺癌患者血清中内皮抑素的表达水平是预测肿瘤恶性行为的有效指标。

Objective： To study the relationship between serum endostatin levels and pathophysiologocal characteristics in the patients with primary lung cancer. Methods： The expression of serum endostatin was detected in 70 lung cancer patients before surgery and 20 healthy persons. The association between serum endostain levels and clinicopathological features was analyzed. Results： Serum endostatin levels in pulmonary carcinoma patients were significantly higher than those in healthy persons. The expression of endostatin was closely related to the size of primary tumor, distant metastasis of the cancer, p-TNM stages and cell differentiation of lung cancer（P〈0.05）, but not to the histological classification, lymph node status, age and sex of the patients with lung cancer（P〉0.05）. Conclusion： The expression of serum endostatin in lung cancer patients might be helpful to evaluate the biological behavior of lung cancer.