脑卒中并发深静脉血栓形成患者测定凝血、抗凝血指标的临床意义

Detection of plasma coagulants and anticoagulants in patients of cerebral infarction with deep vein thrombosis and its clinical significance

目的探讨凝血、抗凝血指标在缺血性脑卒中(CI)并发下肢深静脉血栓形成(LDVT)中的意义。方法检测了50例CI并发LDVT患者和50例健康人血管性血友病因子(vWF)、P选择素(GMP140)、凝血酶原片断1+2(F1+2)、总蛋白S(PS)含量及抗凝血酶(AT)、蛋白C(PC)、纤溶酶原(PLg)、纤溶酶原激活抑制物1(PAI1)活性。结果CI并发LDVT患者的vWF、GMP140、F1+2含量及PAI1活性明显高于正常对照组;总PS含量,AT、PC、PLg活性明显低于正常对照组。结论血液的高凝状态是缺血性脑卒中并发深静脉血栓形成的主要因素。

Objective To explore the roles of coagulant,anticoagulant in patients of cerebral infarction with deep vein thrombosis in Lower Limb. Methods Molecular markers of coagulant, anticoagulant were assayed in 50 patients with deep venous thrombosis in lower limb and 50 normal controls. Parameters include： the level of vWF, GMP-140. F1,2, the total level of protein S （PS） , the activity of antithrombin （AT）, protein C （PC）, plasminogen （PLg） and plasminogen activator inhibitor-1 （PAl-1 ）. Results The level of vWF, GMP-140, F1 ＋ 2 and PA1-1 in the deep venous thrombosis group were significantly increased compared with those of the controls;the levels of AT, PS, PC and PLg in the deep venous thrombosis group were significantly decreased compared with those of the controls. n patients of cerebral infarction with deep vein thrombosis.