IgA-抗组织转谷氨酰胺酶抗体在慢性肝病患者中的表达

Expression of IgA anti-tissue transglutaminase antibodies in patients with chronic liver disease

目的了解IgA抗组织转谷氨酰胺酶(tTG)抗体在慢性肝病患者中的表达。方法以ELISA法检测26例慢性肝病患者(16例慢性肝炎,10例肝硬化)血清IgA抗tTG抗体水平,结果>10AU为阳性。结果26例慢性肝病患者中有4例IgA抗tTG抗体阳性(15.4%),且该4例患者均为乙型肝炎肝硬化病例。ChildPughB级患者的抗体阳性水平略高于ChildPughA级。结论慢性肝病患者中存在较高的IgA抗tTG抗体表达水平,且与门脉高压密切相关。

Objective . To investigate the expression of IgA anti-tissue transglutaminase （tTG） antibodies in patients with chronic liver disease. Methods Twenty six patients with chronic liver disease, including 16 chronic hepatitis and 10 cirrhosis, were evaluated for IgA anti-tTG antibodies by ELISA. Result with value higher than 10 AU were considered positive. Results Four out of 26 （15.4%） were positive of anti-tTG antibodies. In the present study, all patients with positive results had liver cirrhosis. The values of anti-tTG antibodies were slightly higher in Child-Pugh class B cirrhotic patients with positive result than in Child-Pugh class A. Conclusion There was a high prevalence of anti-tTG antibodies in patients with chronic liver disease, and it was associated with portal hypertension.