心肌钙蛋白T在急性冠状动脉综合征临床分型和危险分层中的应用

The clinic application of cardiac troponin T in clinical classification and risk delamination of acute coronary syndrome

目的探讨血清心肌钙蛋白T(cTnT)在急性冠状动脉综合征(ACS)临床分型和危险分层中的作用,评价cTnT水平与ACS的危险程度、心脏事件的发生率及预后的相关性。方法应用电化学发光免疫分析法检测急性心肌梗死(AMI)患者血清cTnT水平,临床诊断性能(ROC)曲线确立cTnT在AMI诊断中的决定限。结果用cTnT升高与否来判断ACS患者是否发生AMI,其诊断敏感性为100%,特异性为95.3%,AMI患者cTnT水平与其危险性相关。结论根据cTnT水平进行ACS的临床分型,能快速、准确的诊断非ST段抬高的AMI,比采用传统分型更科学、可靠与实用,更符合疾病发生的病理生理和临床特征。

Objective To investigate the effect of serum cTnT in the clinical classification and risk delamination of acute coronary syndrome（ACS）. To estimate the relationship between level of cTnT and the patient＇s criticality,heart events rate, prognosis. Methods The serum cTnT concentration of AMI patients was detected by the electrochemiluminescenee immunoassay（ECLIA）. To establish the lower limits of cTnT in AMI diagnosis with ROC curve. Results We can judge whether AMI happened or not in ACS patients according to the level of cTnT. The diagnostic sensitivity is 100% and specificity is 95.3%. Its risk correlates with the cTnT level of AMI patients. Conclusion According to the cTnT level to classify the ACS patients, it can diagnose the non-ST segment elevation AMI quickly and accurately. And it is more scientific, reliable and practical than traditional methods, and conform to pathophysiology and clinical feature of the disease.