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脂联素球状结构域研究进展 被引量：1

Progress of researches on globular domain of adiponectin
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摘要 脂联素球状结构域(gAd)与脂联素受体1(AdipoR1)有很高的亲和力,本文概述了其增加胰岛素的敏感性、抑制胰腺β细胞的凋亡、促进脂肪酸的氧化、抑制粥样硬化性疾病的生理学功能。
作者 杨泽华 解军
机构地区 山西医科大学生物化学与分子生物学教研室
出处 《国外医学（临床生物化学与检验学分册）》 2005年第9期624-627,共4页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词 脂联素 脂联素球状结构域 受体 脂联素受体 结构域 球状 胰腺Β细胞 生理学功能 粥样硬化 亲和力 敏感性 胰岛素
分类号 R341 [医药卫生—基础医学]
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参考文献13

  • 1Maeda K, Okubo K, Shimomura I, et al. cDNA cloning and expression of a novel adipose specific collagen-like factor apM1(adipose most abundant gene transcript 1). Biochem Biophys Res Commun, 1996,221(2): 286-289.
  • 2Scherer PE, Williams S, Fogliano M, et al. A novel serum protein similar to C1q produced exclusively in adipocytes. J Biol Chem.1995,270(45):26746-26749.
  • 3Fruebis J, Tsao TS, Javorschi S, et al. Proteolytic cleavage product of 30-KD adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss. Proc Natl Acad Sci USA, 2001,98(4):2005-2010.
  • 4Yamauchi T, Kamon J, Ho Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature,2003,423(6941):762-769.
  • 5Tsao TS, Murrey HE, Hug C, et al.Oligomerization state-dependent activation of NF-κB signaling pathway by adipocyte complement-related protein 30 KDa(Acrp30).J Biol Chem,2002,277(33):29359-29362.
  • 6Hu XB, Zhang YJ, Zhang HT, et al. Cloning and expression of adiponectin and its globular domain,and measurement of biological activity in vivo. Sheng Wu Hua Xue yu Sheng Wu Wu Li Xue Bao(Shanghai),2003,35(11):1023-1028.
  • 7Ceddia RB, Somwar R, Maida A, et al. Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia, 2005, 48(1): 132 -139.
  • 8Wu XD, Motoshima H, Mahadev K, et al. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocyte.Diabetes,2003, 52(6):1355-1363.
  • 9Yamauchi T, Kamon J, Waki H,e t al. Globular adiponectin protected ob/ob mice from diabetes and apoE-deficient mice from atherosclerosis. J Biol Chem,2004,278(4):2461-2468.
  • 10Rakatzi I, Mueller H, Ritzeler O, et al. Adiponectin counteracts cytokine- and fatty acid-induced apoptosis in the pancreatic beta-cell line INS-1.Diabetologia,2004,47(2):249-258.

同被引文献20

  • 1刘利梅,赵亚莉,李丽,吴立玲.脂联素的信号转导通路[J].生理科学进展,2005,36(2):130-132. 被引量：18
  • 2俞匀,朱大龙.脂联素及其受体研究进展[J].医学研究生学报,2005,18(9):841-844. 被引量：6
  • 3柏家林,蔡葵蒸.脂联素及其受体基因研究进展[J].两北民族大学学报:自然科学版,2012,33(1):35-40.
  • 4Brown JE, Conner AC, Digby JE, et al. Regulation of beta-cellviability and gene expression by distinct agonist fragments of adipone- ctin[ J]. Peptides,2010,31 (5) :944-949.
  • 5Wijesekara N, Krishnamurthy M, Bhattacharjee A, et al. Adiponectin- induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secre- tion[ J]. J Biol Chem,2010,285 (44) :33623-33631.
  • 6Okamoto M, Ohara-Imaizumi M, Kubota N, et al. Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration [ J ]. Diabetologia,2008,51 ( 5 ) : 827-835.
  • 7Winzell MS, Nogueiras R, Dieguez C,et al. Dual action of adipone- ctin on insulin secretion in insulin-resistant mice [ J ]. Biochem Biophys Res Commun ,2004,321 ( 1 ) : 154-160.
  • 8Jtirimae J, J0rimae T, Ring-Dimitriou S, et al. Plasma adiponectinand insulin sensitivity in overweight and normal-weight middle-aged premenopausal women [ J ]. Metabolism,2009,58 (5) :638 -643.
  • 9Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling[ J ]. Diabetes Care ,2004,27 ( 6 ) : 1487-1495.
  • 10Chailurkit LO, Chanprasertyothin S, JongjaroenprasertW, et al. Differences in insulin sensitivity, pancreatic beta cell function and circulating adiponectin across glucose tolerance status in Thai obese and non-obese women [ J ]. Endocrine,2008,33 ( 1 ) : 84-89.

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国外医学（临床生物化学与检验学分册）
2005年 第9期

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