摘要
本研究用“等电临界法”制备O-羧甲基甲壳胺甲氨喋呤毫微粒并在模拟人工胃液、肠液和1%新鲜小鼠血清中进行控释试验,结果表明抗癌药物与载体材料不同的投料比,交联剂用量及释药介质均对毫微粒的释药速度产生影响。
Nanoparticles (Np) of Methotrexate (MTX) were prepared using O-Carboxymethylate chitosan (O-CMC) as wall-forming materials, and an isoelectric-critical technique under ambient conditions. Drug controlled releases were studied in several media including simulated gastric fluid, intestinal fluid and 1% fresh mice serum. It was found that acidic media provided a fast release rate than neutral media. The effect of MTX/O-CMC ratio and amount of cross-linking agent on drug release in different media were evaluated. The changes of size and effective diameter of O-CMC Np were detected by SEM and laser light scattering system before and after drug release. The O-CMC nanoparticles might constitute an attractive alternative to other anticancer drugs and enzyme carriers.
出处
《中国生物医学工程学报》
CSCD
北大核心
1996年第2期102-106,共5页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金
关键词
毫微粒
控制释放
甲氨喋呤
抗癌药
高分子材料
Nanoparticle
Controlled release
O-Carboxymethylate chitosan
Methotrexate