几种药物抑制EB病毒壳抗原在体外细胞中表达的作用

INHIBITORY EFFECT OF SOME MEDICINES ON THE EXPRESSION OF VIRAL CAPSID ANTIGEN OF EPSTEIN-BARR VIRUS IN B95-8 CELLS

ＥＢＶ和ＮＰＣ有密切的关系，用三氮唑核苷、聚肌胞、柴胡、鱼金、板兰根、抗毒清咽合剂按不同浓度加入到能自发产生ＥＢＶ的Ｂ９５－８细胞悬液中，这几种药物均有一定的抑制细胞中ＥＢＶ－ＶＣＡ表达的能力，其中三氮唑核苷（１０μｇ／ｍｌ）、板兰根（１０ｍｇ／ｍｌ）和抗毒清咽合剂（１：１０００）则有较强的抗ＥＢＶ作用，抑制率分别达到了５５．５６％、５７．８９％和５４．１７％，而聚肌胞、柴胡、鱼金的抑制作用较弱。实验结果表明，用药物抑制ＥＢＶ的复制和表达，有可能作为控制ＮＰＣ的方法之一。

There is a closed relationship between EBV and NPC. Rivavirin,Poly IC,Glucurolactone,Isatis Indigatica,Radix Bupleuri,Houttuynia Cordata Flos Lonicerae,and Kangdu Qingyan Mixture wereadded to the culture medium of B95-8 cells,which can produce EBV spontaneously. The expression ofVCA of EBV under various drug concentrations was studied.Except Glucurolactone,all the tested medicineshave inhibitory effect on the expression of EBV-VCA. Especially,there ),their in-hibitory rates were 55. 56%,57.8996 and 54.17%,respectively. Results showed that it may be one of im-portant ways to control NPC,using medicines that can inhibit duplication and exprssion of EBV.