应用PROMACE－MOPP方案治疗非何杰金淋巴瘤临床分析

CLINICAL ANALYSIS OF THE PROMACE-MOPP REGIMEN FOR THE TREATMENT OF NON-HODGKIN’S LYMPHOMA

应用ＰＲＯＭＡＣＥ－ＭＯＰＰ方案治疗非何杰金淋巴瘤１０８例。总缓解率为８７．１％（９４／１０８），完全缓解率为５９．２％（６４／１０８）。复治病人总缓解率为７８．１％（２５／３２）；Ｉ～Ⅳ期病人缓解率分别为１００％，９５．２％．８８．４％，７７．８％；ＣＲ率分别为１００％，９０．５％，５５．８％，３６．１％。一、三、五年生存率分别为６８．５２％，４１．６７％，４０．７５％。主要毒副反应为消化道反应、白细胞降低、脱发，部分病例有心电图异常，未见心力衰竭。本方案可作为中、高度非何杰金淋巴瘤的常规方案和复治病人的补救方案。

patients with Non-Hodgking’s lymphoma treated by PROMACE-MOPP regimen werereported.Among all the patients,the overall response rate was 87.1%(94/ 108),the complete remissionrate was 59.2%(64/108).Among relapsed patients,overall response rate was 78.1%(25/32).Among pa-tients with the stage I,II,III,or IV,overall response rates were 100%,95.2%,88.4% and 77.8%,re-spectively,complete remission rates were 100%,90.5%,55. 8% and 36.5%. Survival rates at 1,3 and 5years were 68.5%,41.6% and 40.7%, The main toxicities were gastrointestinal toxicities and leukopenia.Some patients had abnormal EKG,but no heart failure was occurred.So this regimen can be considered as aroutine and salvage regimen for intermediate-high grade Non-Hodgkinp’ s lymphoma and relapsed pa- tients.