超氧化物歧化酶防治口腔粘膜炎性损害的动物实验研究——炎症介质的动态变化及比较

Protective Effects of Superoxide Dismutase(SOD) Against Paraquate(PQ) Induced Inflammation in Anilam Oral Mucosa: Kinetic Studies on Inflamatory Mediators

采用荧光分光光度法和放射免疫法，研究不同时段炎性组织中炎症介质组胺和前列腺素Ｅ２（ＰＧＥ２）的变化特点，从另一方面了解超氧化物歧化酶（ＳＯＤ）防治甲基紫精（ＰＱ）诱导的口腔粘膜炎性损害的机理。结果表明：炎症早期以组胺为主，中、晚期则以ＰＧＥ２为主，二者似产生协同作用。ＳＯＤ能使这两种活性物质减少，推测其机理可能是因为清除了过量Ｏ－２而间接抑制了炎症介质的合成及释放。

The purpose of this study was to utilize the spectrofluorometry and radioimmunoassay respectively to assay the inflammatory mediators such as histamine and prostaglandin E 2 (PGE 2 )in hamster cheek pouch mucosa in different time. Thus the mechanisms of SOD for its anti inflammation action could be further understood. The results showed that histamine predominated in the early stage, whereas PGE 2 became more intense during the later periods.The concentrations of these two mediators in the SOD group were lower than those of the control group(P<0.05). The results indicated that SOD might inhibit synthesis and generation of these two inflammatory mediators indirectly by the way of scavenging O - 2 in tissues.