超氧化物歧化酶防治口腔粘膜炎性损害的动物实验研究——组织病理学特征及定量比较

Protective Effect of Superoxide Dismutase(SOD) Against Paraquat (PQ) Induced Inflammation in Animal Oral Mucosa:Histologic Characterization and Quantitative Comparison

本实验通过肉眼、光镜、电镜观察以及计算机数字图象分析技术，对超氧化物歧化酶（ＳＯＤ）防治甲基紫精（ＰＱ）诱导的金黄地鼠口腔粘膜炎性损害的效果进行评价。同时，详细描述、比较了ＳＯＤ组和对照组口腔粘膜组织形态学变化特征。结果表明：局部注射ＳＯＤ能明显减轻金黄地鼠粘膜组织的炎症损害。这为ＳＯＤ用于临床治疗口腔粘膜炎性疾病提供了较可靠的实验依据。

This study assessed the protective effect of SOD against the PQ induced inflammation in the hamster cheek pouch mucosa by macroscopy, light and electron microscopes.In addition, a detail histologic characterization of the mucosal injury in SOD group and the control group was reported. The lesions were also subjected to a histomorphometric analysis with the use of a computerized digitizing system. The results showed that the inflammation of hamster oral mucosa could be significantly reduced by local injection of SOD.Thus application of SOD to the clinical use for the oral mucosal diseases is strongly indicated.