乳腺癌细胞核形态与预后关系的定量研究

The prognostic value of morphometry in breast cancer with different clinical pathological features

应用图象分析技术测定５７例乳腺癌细胞核形态参数，观察它们在不同临床病理状况下与预后的关系。结果显示，雌激素受体阴性、淋巴结有转移的、低分化单纯癌及５０岁以下患者，细胞核大则生存期较短；而无淋巴结转移、高分化导管浸润癌及５０岁以上患者，大核乳腺癌术后５年生存率较高。生存组细胞核形状因子较大，且与各临床病理因素无明显相关。

The prognostic value of morphometric parameters in 57 patients with breast carcinoma of different clinical pathological features was studied.In groups of estrogen receptor negative,nodal involved, poor differentiated carcinoma simplex and patients younger than 50,the patients who died in 5 years after mastectomy owned larger cancer cell nuclei than those surviving for more than 5 years, In groups of nodal negative, well-differentiated invasive ductal carcinoma and patients older than 50,there was a better prognosis when the nuclei were large. In patients surviving for more than 5 years the values of nuclear shape factors were larger and they had no significant relation to different clinical and pathologic features.