AgNOR在骨巨细胞瘤分级及预后判定中的价值

Prognostic and classificatory value of AgNOR counts in giant cell tumors of bones

对４２例骨巨细胞瘤（ＧＣＴ）患者进行ＡｇＮＯＲ计数，其中Ⅰ级１８例，Ⅱ级１４例，Ⅲ级１０例。结果发现ＡｇＮＯＲ在Ⅰ级与Ⅱ级瘤间差异无显著性（Ｐ＞０．０５），而在Ⅰ级与Ⅱ级瘤间差异有高度显著性（Ｐ＜０．０１）。提示ＡｇＮＯＲ的表达与Ｊａｆｆｅ分级不太一致。因而，我们倾向于将骨ＧＣＴ只分为良、恶性两种，而且ＡｇＮＯＲ的高低与骨ＧＣＴ的预后有关。

Silver-binding nucleolar organizer regions (AgNORs) were counted in 42 cases of giant cell tumors (GCT) of bones. Of them 18 cases belong in grade Ⅰ,14 cases belong in grade Ⅱ and 10 cases belong in grade Ⅲ.The results showed the difference between Ⅰ and Ⅱwas not significant (P>0.05), but between Ⅱand Ⅲ was significant(P<0.01).This indicated that the expression of AgNORs was different from Jaffe's classification.Therefore,we tend to classify GCT of bones in benign and malignant.At the same time,the expression of AgNORs was related to prognosis of patients with GCT of bones.