90例乳腺良性病变组织中ER和PR的表达

Expression of ER and PR in bengin breast diseases of 90 cases

应用免疫组化方法对９０例良性乳腺病变组织进行ＥＲ、ＰＲ的检测。结果：ＥＲ阳性率为８４．４％，ＰＲ为８３．３％，与同期乳腺癌的ＥＲ和ＰＲ阳性率相比较有非常显著性意义。ＥＲ阳性以纤维腺瘤、导管内乳头状瘤、囊性乳腺增生症最为常见，小叶内增生ＥＲ阳性相对减少。同时对乳腺组织间质中存在有背景染色问题加以讨论。

cases of benign breast diseases were evaluated for estrogen and progesterone receptors(ER, PR) by immunohistochemical technique.The results showed that 84.4%were ER positive and 83.3% were PR positive in benign breast diseases. There were significant statistical difference between benign breast diseases and breast cancers for ER positivity and PR positivity (P< 0.01).The fibroadenoma,ductal papillomatosis and cystic disease were the most frequent ER positive, whereas the intralobular proliferation only rarely contained ER.The background staining in benign breast diseases for ER, PR was discussed.