尼莫地平对大鼠急性脑缺血再灌注损伤的作用(英文)

Effects of nimodipine on acute cerebral ischemia and reperfusion injury of rats

目的:研究尼莫地平(Nim)对脑缺血损伤的作用。方法:大鼠脑缺血模型采用四血管结扎法(4-VO),单胺递质测定采用荧光分光光度法。结果:腹腔注射尼莫地平0.75mg·kg^(-1)和1.5mg·kg^(-1)能显著改善缺血再灌注损伤的脑电活动,脑电恢复时间可恢复到19±3min和17±4min(P<0.01),尼莫地平还能明显减轻缺血30min后再灌注1h的单胺递质的降低。结论:Nim对缺血引起损伤的神经有保护作用。

AIM: TO study the effect of nimodipine (Nim) on ischemic cerebral damage. METHODS: The four-vessel occlusion method was performed on rats. Monoamines were measured by fluoro-spectrophotometry. RESULTS: Intraperitoneal injection of Nim 0.75 and 1.5 mg·kg-1 quickened the recovery of EEG changes to 19 ± 3 and 17 ± 4 min(P<0.01), respectively. Nim reduced the decreases of monoamines (NE, DA, 5-HT, and 5-HIAA) contents after 30-min cerebral ischemia and 1-h reperfusion. CONCLUSION: Nim protects the brain from ischemic damage.