在大鼠群居相互接触模型上纳曲酮的致焦虑作用(英文)

Anxiogenic effect of naltrexone in social interaction test in rats

目的:观察纳曲酮(Nal)对焦虑情绪的影响。方法:在群居焦虑模型上观察给予Nal等药后配对大鼠主动接触时间的变化。结果:Nal(0.1—50mg·kg^(-1))明显减少大鼠在强光不熟悉环境下的主动接触时间,且有剂量和时间依赖关系,并可被吗啡(5mg·kg^(-1))和5-HT合成抑制剂Fen(150mg·kg^(-1)×3d)所拮抗,为5-HT合成前体5-HTP(50mg·kg^(-1))所增强。而Nal对大鼠运动性活动无显著影响。结论:Nal使动物产生焦虑状态;中枢阿片肽能神经通过其对5-HT能神经的紧张性抑制作用参与焦虑情绪的调控。

AIM: To study the anxiogenic effect of naltrexone (Nal) on the emotional state of rats. METHODS: The duration of active interaction was measured in the social interaction test in rats. RESULTS: Without influence on the locomotor activity, Nal (0.1 -50 mg·kg-1) dose- and time-dependently decreased the duration of active interaction, which was antagonized by morphine (5 mg · kg-1) or fenclonine (Fen, 150 mg · kg-1 × 3 d) and was enhanced by 5-hydroxytryptophan ( 5-HTP, 50 mg·kg-1). CONCLUSION: Nal produced anxiety via its blockade of opioid receptors; central opioidergic neurons were involved in the regulation of anxiety through their tonic inhibitions in serotonergic neurons.