脑智通胶囊与脑复活对血管性痴呆患者智能及血浆降钙素基因相关肽作用的比较

Naozhitong versus Naofuhuo in improvement of intelligence and plasma calcitonin-gene-related peptide of vascular dementia patients

目的:观察中药脑智通胶囊对血管性痴呆患者血浆中有强烈舒血管作用的神经肽降钙素基因相关肽的影响,以及对患者智能改善的作用,并与脑复活进行阳性对照。方法:选择2004-01/09黑龙江中医药大学附属第一医院收治的血管性痴呆患者52例。将患者按随机数字表分为脑智通组和脑复活组各26例,脑智通组口服脑智通胶囊(人参、黄芪、黄精、三七组成),4粒/次(1.975g/粒),3次/d;脑复活组口服脑复活片,4片/次,3次/d,两组均连续用药60d。治疗前后采用放射免疫法分别测定两组患者血浆中降钙素基因相关肽浓度,并观察患者治疗后智能改善情况。结果:按意向处理分析,52例患者全部进入结果分析。①血浆降钙素基因相关肽水平:两组治疗后均较治疗前升高(P<0.05),脑智通组治疗后高于脑复活组[(81.83±6.84),(65.23±10.82),P<0.05]。②临床疗效:脑智通组和脑复活组总有效率无差异(81%,73%,P>0.05),但显效率脑智通组高于脑复活组(35%,12%,P<0.05)。结论:脑智通胶囊通过升高降钙素基因相关肽,能扩张脑血管,增加脑血流量,促进神经细胞的能量代谢,使脑神经细胞功能再恢复,从而改善血管性痴呆患者学习记忆功能,效果优于脑复活。

AIM： To probe the influence of Naozhitong capsule versus Naofuhuo tablet on plasma calcitonin-gene-related peptide（CGRP） and intelligence in patients with vascular dementia （VD）. METHODS： Fifty-two VD patients hospitalized in the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from January to September 2004 were enrolled. All the enrolled patients were randomized into Naozhitong group and Naofuhuo group with 26 cases in each group to take Naozhitong capsule orally （composed by ginseng, membranous milkvetch root, king solomonseal rhizome and sanchi）, 4 granules once in eight hours, and to take Naofuhuo tablet orally, 3 tablets once in eight hours. The duration of administration was 60 days continuously. CGRP concentration in blood play, ha was measured by irradiation immunity analytical method before and after treatment, and the changes in the intelligence of patients were observed. RESULTS： According to the intention-to-treat analysis, 52 patients all entered the result analysis. ①The concentration of CGRP were elevated after the treatment in both groups （P〈 0.05）. However, CGRP concentration in Naozhitong group was higher than that of Naofuhuo group[（81.83±6.84）, （65.23±10.82）ng/L,P〈0.05]. ②There was no difference in the total efficiency between the two groups （81% ,73% ,P 〉 0.05）, hut the obvious effect in the Naozhitong group was higher than that of Naofuhuo group（35%, 12% ,P 〈0.05 ）. CONCLUSION： By means of CGRP increase, Naozhitong capsule can expand blood vessel of brain, increase brain blood flow, expedite the energy metabolism of nerve cells and renew the function of brain nerve cells. Accordingly, the function of leanring memory can be enhanced.